Journal Club for Immunology (n=19+more ~ 50)

2020/08/20–CAF系列3/3: Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts (PubMed Link) 林素芳 (此研究以scRNA-seq方法比較人體PDAC及KPC鼠隻腫瘤檢體 stromal cell population之異同 pdf 5627 DA Tuveson Lab)

◉ p.1110 Single-Cell Analysis of KPC Tumors Recapitulates Human PDAC
𑁍Similar to human PDAC, KPC tumors contained a preponderance (∼87%) of myeloid cells, consisting of mostly macrophages and neutrophils, with a small subset of DCs (Fig. 4A and B).𑁍
𑁍However, mouse PDAC was distinct in its substantially lower fraction of B and T lymphocytes, in agreement with reports showing exclusion of T cells from pancreatic tumors in mouse models (ref 17, 55).𑁍
𑁍The fraction of fibroblasts in the KPC tumors was similar to that of human PDAC samples (2% of all cells ≈225顆…). With the exception of the “epithelial-to-mes- enchymal transition (EMT)–like cells” (cluster 12) that came from a single KPC tumor, all cell types were represented in all four KPC tumors.𑁍

◉Analysis of Fibroblasts in KPC Tumors Reveals a Novel CAF Subtype with Antigen Presentation Features

2020/12/10 (終場秀 👏👏👏)
Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice
(PubMed Link) 彭佳敏
 
2020/11/24
Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP
(PubMed Link) 陳明玉
 
2020/11/12
Early precursor T cells establish and propagateT cell exhaustion in chronic infection
(PubMed Link) 謝小燕
 
2020/10/29
Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19
(PubMed Link) 蔡佩汝

 
2020/10/15
Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors (PubMed Link) 彭春怡
 

2020/09/17

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage (PubMed Link) 詹博強
 
2020/09/03
Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis (PubMed Link) 鄭雲心

2020/08/20
CAF系列3/3: Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts (PubMed Link) 林素芳 (此篇文章中提及人類PDAC及鼠隻PDAC stromal cell population 截然不同 pdf 5627 )

2020/07/16
Negative Regulation of Dendritic Cell Activation in Psoriasis Mediated via CD100-plexin-B2 (PubMed Link) 陳欣欣

2020/07/02
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFa to Shape CAF
Heterogeneity in Pancreatic Ductal Adenocarcinoma (PubMed Link) 賴亭羽

2020/06/18
Uncoupling Protein 2 Reprograms the Tumor Microenvironment to Support the Anti-Tumor Immune Cycle (PubMed Link) 陳明玉

2020/06/04
Germinal Center B Cells Selectively Oxidize Fatty Acids for Energy While Conducting Minimal Glycolysis (PubMed Link) 蔡佩汝

2020/05/21
Human Chimeric Antigen Receptor Macrophages for Cancer Immunotherapy (PubMed Link) 周文敏

2020/04/23
Identification of essential genes for cancer immunotherapy. (PubMed Link) 陳玉蓮

2020/04/09
Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape. (PubMed Link) 鄭雲心

 
2020/03/19

Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. (PubMed Link) 劉又慈

 
2020/03/05

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets. (PubMed Link) 柯英潔

2020/02/20
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways. (PubMed) 劉奕宏

 
2020/02/06

Programmable bacteria induce durable tumor regression and systemic antitumor immunity. (PubMed Link) 楊育韶

 
 

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