DDR1 in cancer cell collective migration

The discoidin domain is responsible for slime mode aggregation
adapted from Pauline Schaap, “Evolutionary crossroads in developmental biology: Dictyostelium discoideum” Development, 2011, Fig. 1. (https://doi.org/10.1242/dev.048934)
The Tang Lab

2005 Wang et al., Function of discoidin domain receptor I in HGF-induced branching tubulogenesis of MDCK cells in collagen gel (15468059) | 2006 Wang et al., A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration (16611743) | 2009 Yeh et al., RDiscoidin domain receptor 1 activation suppresses alpha2beta1 integrin-dependent cell spreading through inhibition of Cdc42 activity (18780290) | 2009 Wang et al., DDR1/E-cadherin complex regulates the activation of DDR1 and cell spreading (19474292) | 2010 Eswaramoorthy et al., DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation (20432435) | 2011 Yeh et al., DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin (21289093) | 2012 Yeh et al., A tale of two collagen receptors, integrin beta1 and discoidin domain receptor 1, in epithelial cell differentiation (23015544) | 2019 Yeh et al., Dichotomy of the function of DDR1 in cells and disease progression (30954568)

The Sahai Lab (G-Scholar)

2007 Gaggioli et al., Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells (18037882) | 2011 Hidalgo-Carcedo et al., Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6 (21170030) | 2014 Hirata et al., Retrograde flow of cadherins in collective cell migration (24981633)

Our Lab (G-Scholar)

2012 蔡宛樺 et al., Overexpression of Discoidin Domain Receptor 1 (DDR1) in oral squamous cell carcinoma (Poster @ EORTC-NCI-AACR molecular targets and cancer therapeutics symposium) | 2019 Chou et al., MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1 (31253192)| 2020 陳玉蓮 et al., Discoidin Domain Receptor-1 (DDR1) is Involved in Angiolymphatic Invasion in Oral Cancer (32244515)

People who cited our DDR1 paper! (GoogleTrack)

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