a picture is worth a thousand words, a video is worth a million.
Rho/Rac/Motility 這裡.
Amoeboid-like and mesenchymal-like.
Rta不知道有沒有granzyme B的site. 這裡. PCSK1會切KR嗎?
Cellular senescence is one step to tumor
Ras-Nature paper
Weinberg’s theory with Stem cell-like
Tlsty’s theory
Prostate/Melanoma
HDACi as anti-cancer drug
Pelicci. 2006. Histone deacetylase inhibitors and the
promise of epigenetic (and more) treatments for cancer. Nat. Rev. Cancer
6:38–51.
Bolden, J. E., M. J. Peart, and R. W. Johnstone. 2006. Anticancer activities
of histone deacetylase inhibitors. Nat. Rev. Drug Discov. 5:769–784.
EBV immediate-early protein Rta induces cellular senescence
Cellualr senescence and EBV reactivation and EBV associated malignancies
2006. Valproic acid enhances the efficacy of
chemotherapy in EBV-positive tumors by increasing lytic viral gene expression.
Cancer Res. 66:8762–8769.