2009/03/04
Dr. Lin’s laboratory is directed at studying the oncogenic mechanisms of human herpesviruses including EBV and KSHV: (1) it is not completely understood why only the minority of EBV infected individuals suffered from cancers, while the majority can be waived; (2) it is mysterious why most of the reported EBV and KSHV encoded onco-proteins are not expressed in vivo; (3) continuously periodic lytic cycle replications of EBV and KSHV have been clinically implicated in tumorigenesis; (4) comparative genomic studies have revealed significant identities between EBV and KSHV, providing information regarding common pathways that these two oncogenic herpesviruses employ to participate in the pathogenesis of human malignancies.