HKU-NHRI Joint Symposium
Monday, 03-28, 2011
Session I Metabolic Disease (Co-chaired by Pak Sham (沈伯松) and Tse-Hua Tan)
1. Health Aging Research at HKU (Karen Lam (林小玲))
2. Healthy Aging Longitudinal Study in Taiwan (HALST, by Chau Agnes Hsiung, NHRI)
3. Adipokines in obesity-related cardio-metabolic complications (Aimin Xu 徐愛民)
(goodies: adipokine; baddies: IL6, TNF-a, A-FABP etc)
4. Cardiometabolic disease in Taiwan (Wen-Harn Pan, NHRI)
Session II Model Organisms (Co-chaired by Karen Lam and Lu-Hai Wang)
5. Zebrafish ugly duckling (Udu( is involved in henatopoiesis and beyond (Yun-Jin Jiang, NHRI)
6. When hematopoiesis goes awry- a study of human leukemia based on the zebrafish model (Anskar YH Leung (梁如鴻)) setup a zebrafish screening platform for ALL.
7. Roles of MAP4Ks and DUSPs in lymphocyte signaling and human diseases (Tse-Hua Tan)
Tuesday, 03-29-2011
Session III Cancer and stem cell (Co-chaired by Paul Tam 副校長譚廣亨 and Jang-Yang Chang)
8. HK-wide stem cell initiative: a multi-site network of cell-based heart regeneration as a case study (Ronald Li 李登偉)
9. Liver cancer trial in NHRI (Li-Tzong Chen, NHRI)
10. Overview for centre of cancer reserach/ EBV infection in nasopharyngeal carcinoma (George Tsao 曹世華)
11. Identification and functional analysis of tumor suppressor genes in nasopharyngeal carcinoma (Marie Lung, 龍李梅瑞)
12. Molecular portraits of structural differentiation predict prognosis in glandular cancers (Kelvin Kun-Chih Tsai, NHRI: 56-gene universal prognostic predictor for general cancers)
13. Molecular genetic study of hepatocellular carcinoma (Irene Ng, MD, Ph.D 吳呂愛蓮)
Session 4. Genomics (Co-chaired by Aimin Xu and Shih-Feng Tsai)
14. Genetic determinants of antimicrobial resistance of a superbug carrying the NFM-1 gene (Prof Tsai, NHRI)
15. Superbug, Feng-Chi Chen (The metabolic network)
16. Prospects for genetic risk prediction for complex diseases (Pak Sham: collaborates with Paul Tam 副校長Colorectal cancer GWAS, Illumina 610Quad at deCODE; GATES: a rapid and powerful gene-based association that using extended slided procedures, knowledge-based mining system for genome-wide genetic structures, predicting risk factor/family/history and known susceptibility genes)
Collaboration Brainstorm (George Tsao and Lu-Hai Wang)
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George and Maria’s talks:
1. NPC incidence was cut-down 14% in the past decade.
2. Good photo for Nasopharynx
3. hypoxia
4. 3p (RASSF1), 9 p (p16)
5. Lo, KW (2004 Cancer cell paper)
6. chromosomes 3, 9, 11, 14
7.cyclin D1 and CDK4 prevents EBV infection induced senescence.
8.NP351hTert, NP461hTert, NP550hTert. 10% success rate.
9. TGFb increases infection rate; IL6/STAT3/ increases latency/persistent infection.
10. H2O2 induced senescence (0-50-100-150-200 uM?)
11. Current opinion in pharmacology (good paper)
12. Microcell-mediated chromosome transfer (MMCT)
micosatellite typing (HONE1 vs. chromosome 11)
Expression (qRT-PCR, TMA, inactivation etc)
Angiogenesis
Tumorigenesis
Metastasis
She follows Weinberg and Hanahan’s Hallmarks paper
13. chromosomes 3 (RASFF1, PTPRG), 9 (p16), 11, 12 (DUSP6, MMP19), 14 (CRIP2)
14. CRIP2: (a) cystene-rich intestine protein 2, maps to 14q32.33, a region of high alleic loss in NPC, important in regulating angiogeneiss (b) is under-expressed in 5/7 (70%) (HONE1, HNE1, CNE1, C666-1, SUNE1; not changed in CNE2, and increased in HK1. George suspected HK1 is not a typical NPC cell line); CRIPs interacts with p-p65 and inhibits NF-KB function in transactivating IL6, IL8 and angiogenesis-related genes.
15. New NP lines (NP361 abd NP550) hTert immortalized, ring-cloning (~250 passages)
16. Ana Tsang (is the one experienced in EBV infection)
17. NP460hTert + IL6 => pSTAT3 increases. => myc and CCND1 increases.
18. (Published in Cancer cell ? ) IL6 and LMP1 and STAT3 form a positive-loop.