7:00 PM Keynote Address IV Shannon Hall
Oral Talk #96
Repetitive Structures Produce Highly Immunogenic Vaccines
Against Papillomaviruses, Polyomaviruses, and Epstein-Barr
Virus
Douglas Lowy1
1National Cancer Institute
Against Papillomaviruses, Polyomaviruses, and Epstein-Barr
Virus
Douglas Lowy1
1National Cancer Institute
1. Virus infection and human cancer: an overview
Schiller JT, Lowy DR.Recent Results Cancer Res. 2014;193:1-10. doi: 10.1007/978-3-642-38965-8_1.
PMID: 24008290
2. Vaccines to prevent infections by oncoviruses.
Schiller JT, Lowy DR.
Annu Rev Microbiol. 2010;64:23-41. doi: 10.1146/annurev.micro.112408.134019. Review.
PMID: 20420520
Virus-like particles (VLPs)
B cells specifically recognize particulate antigens with epitope spa in golf 50-100 A as foreign
HPV virus-like particles
USA-HPV+ cancers
OPC in man (70%)
Quadrivalent HPV vaccine safety reviews and
High efficacy of HPV L1 VLP vaccines again new cervical precancerous and genital warts by vaccine targeted types in randomized trial
Precancerous =cervical intraepithelial neoplasia grade 3(the first successful sex-transmitted viral cancer vaccine!
Directly reduce risk of infection and disease in vaccines
Herd Immunity! (Also decrease in warts numbers in men with heterosexual in Austral)
1,2,or 3 dose she if bivalve this vaccine confer at least 7 years of protection against incident HPV 16/18/31/33/.45 infection: Post-NOC analysis
% change in HPV16 VLP ELISA tigers from year 4 to year 7
Even one dose of HPV VLP vaccine induces high avidity antibodies
HBV vaccine is not s immunogenicity
Candidate VLP vaccines Dior BKV and JCV
BKV viremiua following kidney transplantation , can lead to rejection of donor kidney
Bladder cancer: integrated BKV lareget T
Neutralizing antibodies are associated with protection against BKV infection
Smaller than VLPs of papilloma virus
BKV VLPs induce neutralizing antibodies
JCV and progressive multi-focal leukoencephalopathy (PML)
Black box for PML incidence in immunosuppressive therapies
Replicating JCV in PML may escape
A candidate repetitive array vaccine for EBV infections
Joint session 1 10:45 Jeffrey Cohen
Glycoprotein
Gp350 | CR2
GgB
Gp350
Gp42
Gh/gL
BMRF2?
To improve upon soluble gp350 : self-assembling nanoparticle-based vaccines
Ferritin- Kanekiyo et al Cell 2015
Ferritin-gp350 protests mice from challenge with vaccinia circus expression gp350
Contribution f antibody EBV glycoproteins
Antibody B cells | Epithelial cells
gp350 | 50-60 | 5
gH/gL | 20-30 | 75-80
gp42 | 10-20 | ~5
EBV gK/gL +- gp42-ferritin nanoparticles
VLPs display is highly immunogenicity, probably attributable to to long-live plasma cells induced by the repetitive display
聽完這個後(~8PM)就和香港大學與會人士前往 The Great DANE PUB & BREWING (123 E Doty St, Madison, WI53703)聚餐
