2020/08/20–CAF系列3/3: Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts (PubMed Link) 林素芳 (此研究以scRNA-seq方法比較人體PDAC及KPC鼠隻腫瘤檢體 stromal cell population之異同 pdf 5627 DA Tuveson Lab)
◉ p.1110 Single-Cell Analysis of KPC Tumors Recapitulates Human PDAC
𑁍Similar to human PDAC, KPC tumors contained a preponderance (∼87%) of myeloid cells, consisting of mostly macrophages and neutrophils, with a small subset of DCs (Fig. 4A and B).𑁍
𑁍However, mouse PDAC was distinct in its substantially lower fraction of B and T lymphocytes, in agreement with reports showing exclusion of T cells from pancreatic tumors in mouse models (ref 17, 55).𑁍
𑁍The fraction of fibroblasts in the KPC tumors was similar to that of human PDAC samples (2% of all cells ≈225顆…). With the exception of the “epithelial-to-mes- enchymal transition (EMT)–like cells” (cluster 12) that came from a single KPC tumor, all cell types were represented in all four KPC tumors.𑁍
◉Analysis of Fibroblasts in KPC Tumors Reveals a Novel CAF Subtype with Antigen Presentation Features
2020/09/17
Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis (PubMed Link) 鄭雲心
2020/08/20
CAF系列3/3: Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts (PubMed Link) 林素芳 (此篇文章中提及人類PDAC及鼠隻PDAC stromal cell population 截然不同 pdf 5627 )
2020/07/16
Negative Regulation of Dendritic Cell Activation in Psoriasis Mediated via CD100-plexin-B2 (PubMed Link) 陳欣欣
2020/07/02
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFa to Shape CAF
Heterogeneity in Pancreatic Ductal Adenocarcinoma (PubMed Link) 賴亭羽
2020/06/18
Uncoupling Protein 2 Reprograms the Tumor Microenvironment to Support the Anti-Tumor Immune Cycle (PubMed Link) 陳明玉
2020/06/04
Germinal Center B Cells Selectively Oxidize Fatty Acids for Energy While Conducting Minimal Glycolysis (PubMed Link) 蔡佩汝
2020/05/21
Human Chimeric Antigen Receptor Macrophages for Cancer Immunotherapy (PubMed Link) 周文敏
2020/04/23
Identification of essential genes for cancer immunotherapy. (PubMed Link) 陳玉蓮
2020/04/09
Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape. (PubMed Link) 鄭雲心
Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. (PubMed Link) 劉又慈
Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets. (PubMed Link) 柯英潔
2020/02/20
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways. (PubMed) 劉奕宏
Programmable bacteria induce durable tumor regression and systemic antitumor immunity. (PubMed Link) 楊育韶