Wei Dai (The University of Hong Kong, Hong Kong SAR China)“Genetic Susceptibility in Nasopharyngeal Carcinoma” multiple genetic effects in the NPC susceptibility genes allele frequency can WES-seq if NPC identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma [Gene Level replicaiton study in NPC] NPC cases (n=1131, FamilyHIstory FH+=258) MST1R deleterious covariant s of […]
Scott Bratman (Princess Margaret Cancer Centre, Canada)“Circulating Tumor DNA: Detection and Applications in Curable Cancers” Can liquid biopsy replace it’s sue biopsy?EGFR-mutant NSCLC: ctDNA analysis is standard for guiding EGFR How about applied to cancers that are curable CtDNA < 1% total cell DNA Nat Rev Wan… Rosenfield et al. Nat Rev Cancer 2017 Rasta
Maria Lung (University of Hong Kong, Hong Kong SAR China)“New Insights in NPC Detection Utilizing Circulating Tumor Cell Enumeration and NGS Analysis” NPC AoE Research Tissue Bank (http://www.cnpcr.hku.hk/tb1.htm) CTCs and CtDNA (Dr. Lin, JC and Dennsi Lo) provide different and complementary information Cancer Research 2013. (Pastel and Alex Panabieres) Real time liquid biopsy in
Jin-Ching Lin (National Yang-Ming University, Taiwan)“Application of Plasma EBV DNA Assay in Daily Practice of NPC Management” [Tumor Biomarkers in NPC]– serum anti-EBV antibody– Serum/plasma EBV DNA– Others (many molecular markers reported bu no any one can be used clinically) [Comparison of sensivity and specificity In J Radiat Oncol Biol Phys 2007; 67:130-7 [Ideal Tumor
Wei-Hua Jia (Sun Yat-sen University Cancer Center, China)“Genetic Predisposition of Nasopharyngeal Carcinoma: Evidence from GWAS and Sequencing Studies” # Spatial and temporal patterns of MNOC mortality in China (1973-2005) showed significant decreased Compared with those living in North China, residents living in Southern China had a much higher risk in the Familial clustering has been
Lori Frappier (University of Toronto, Canada) “New Functions for EBV Proteins in Manipulating Cellular Processes Important for Cancer” EBV lytic infection and cancer EBV encodes ~ 80 proteins, ~70 of which are only expressed in lytic infection EBV induced cancers are considered to be latent infections but lytic infection is also important because: 1 High
Shannon Kenney (McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, USA) “Differentiation-Dependent Lytic EBV Reactivation in Epithelial Cells” Two models of herpesvirus infection (B cell and epithelials) Latent —> Lytic Latent/B cells Few viral genes expressed Replicated by host cell DNA polymerase Episomal viral DNA helps viruses evade immune response EBV genome is methylated in
Lin Feng (Sun Yat-sen University Cancer Center, China)–”Nasopharyngeal Carcinoma Susceptibility Gene TNFRSF19 Inhibits TGFβ Signaling and Promotes Tumorigenesis” TNFRSF19 susceptibility gene. Nat Genet 2010. Bei JX et al A orphan receptor , no ligand found yet by IHC, TFNRSF19 is highly expressed in NPC tissues, possibly an oncogene Survival TNF receptors noncanonical TNFR of TNFRSF19
Bo Zhao (Brigham and Women’s Hospital / Harvard Medical School, USA) –”NPC Epigenetic Landscapes and Super-Enhancers” Chromatin modifying enzymes are frequently altered in NPC (Lin D et al Nature Genetics 2014) exome-seq results Epigenetic changes are reversible and druggable Super-enhancers are recently discovered enhancers with (1). Extraordinarily wide and tall signals for H3K27ac, BRD4 etc
Rebecca Skalsky (Oregon Health and Science University, USA)“Regulation of Host Signaling Pathways by EBV miRNAs” EBV encodes 25 precursor miRNAs ~100-200 different target sites on mRNAs> 44 EBV miRNAs =significan tregulatory potential MiRNAs are great toools for viruses:– non-immunogenicity– -require limited encoding capacity (only 22 not)-can rapidly evolve; have Lymphocryptoivirus muRNAs are highly conserves Circular