2014

DDR1 manuscript 相關

DDR1 manuscript 相關 由 sufang 在 五, 11/07/2014 – 16:57 發表  Pre-published   CDDis   DDR1   Front Oncology   manuscript 2015/05/08 (Thu)  MS submitted to Research Topic “Oral Oncology” 2015/05/30 (Sat)   MS returned, interactive reviews activated: Editor: Rui Amaral Mendes Catholic University of Portugal; Editor of J Carcinogenesis and Mutagenesis; Adhuant Prof at CWRU 2015/08/28 rejected… by Specialty Chief […]

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TOP-OCC and TOP-OCD

2014/11/12 OPMD IRB: 基因檢測是以單核苷酸多態性(single nucleotide polymorphism, SNP)為主,特別是會影響酵素功能的功能性(functional)SNP與在亞洲人當中比較重要的SNP。SNP的檢測將採用Taqman allele discrimination的方式1。 首先,把DNA的濃度標準化為15ng/µL。然後,在96孔盤裡分別加入84位不同研究對象的DNA與試劑的混合液(2µL=30ng DNA in a 25µL reaction)、8個陽性對照及4個陰性對照,預計共需要24個96孔盤來完成所有研究對象(N=2000)每一個SNP的檢測。接著,把96孔盤放置在Applied Biosystem 7500 real time PCR(Foster City, CA)進行資料的讀取。每一個SNP的檢測將會經過幾個步驟的品質管制:a.    以對照組的檢測資料來評估Hardy-Weinberg disequilibrium,p值<0.01的SNP將被排除。b.    Allele 的頻率將與the International Hapmap Project(www.hapmap.org)2 的中國人的基因資料來做比較。c.    偵測頻率(call rate)< 95%的SNP將被排除。d.    10%的DNA樣本將被重覆檢測來評估檢測的準確度。 1.    de Kok JB, Wiegerinck ET, Giesendorf BA, Swinkels DW. Rapid genotyping of single nucleotide polymorphisms using

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Epigenetic Talks Bing Ren

Dear All, I like to invite you to join two exciting Epigenetic Talks by the world leading scientists Yi Zhang and Bing Ren on Oct 23 and Nov 4, respectively, at Academia Sinica. Bing Ren UCSD Regulation of the 3D Genome 11 am, Nov 4, 2014 B1 Auditorium, IMB, Academia Sinica Dr. Bing Ren, Member of Ludwig

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Tak Wah Mak

由 sufang 在 日, 11/02/2014 – 11:09 發表 Pre-published Cancer Metabolism Notes Youtube https://www.youtube.com/watch?v=nFelWNxpdWk Genomic alterations in cancersmutations (300,000; > 20,000 genes)epithelial : 50-100; leukemia: 20amplifications (3000)deletions (thousands)translocations (fusions: 7000)epigenetic changes (extensive)Drivers : hundred, 90% loss of functionsInter-and intra-tumor heterogeneity (Charles Sweton)< 1/2 mutated or amplified genes expressed Two more oncometabolic papers from Harvard Groups: Nature (2011). Functional

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2014年10月30日癌症研究國際研討會: 從基礎科學到臨床應用

2014年10月30日癌症研究國際研討會: 從基礎科學到臨床應用 由 sufang 在 四, 10/30/2014 – 09:42 發表  Pre-published   cancer of excellence   International symposium on cancer research   Meeting   二期癌症研究計劃   癌症研究國際研討會   衛福部 首頁: http://scr.nhri.org.tw/index.jsp 台大醫院國際會議中心 301會議室 (77240109) 衛福部 許明能次長致辭 龔院長致辭 1. 張元吉教授: Combination targeted therapy in advanced lung cancer 2. 陳慶士教授: Fighting an organized crime network in pancreatic cancer: tumor

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EBV associated malignancies and IDO1 expression

由 sufang 在 二, 10/28/2014 – 14:27 發表 Pre-published EBV EBV associated gastric cancer IDO1 Lymphoproliferative disorders PLoS Pathog. 2013;9(5):e1003341. doi: 10.1371/journal.ppat.1003341. Epub 2013 May 9.Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity: implications for possible immune adjuvant therapy. Strong MJ1, Xu G, Coco J, Baribault C, Vinay DS, Lacey MR, Strong

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10/14 (二) 蕭醫師來訪建議.

由 sufang 在 日, 10/26/2014 – 09:14 發表 Pre-published IDO1 要找IHC能用的抗體,可以上 The human protein atlas網站.像以HNSC IDO1而言,就有三個選擇 HPA023072, HPA023149, HPA027772. 素芳提議染100例oral cancer檢體、或是補染40對T/N samples。 2014/10/28: TDO2也有抗體 Antibody HPA039611.   HNSC TDO2.    IDO2 則似乎沒有收錄.

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Dr. George Prendergast’s visit

由 sufang 在 日, 10/26/2014 – 09:25 發表 Pre-published IDO1 TDO2 Time: 10:00~11:30 October 24, 2014 (Fri) Topic: IDO pathways in pathogenic inflammation and immune escape in cancer Speaker: George C. Prendergast, PhD (CV download) Professor, President & CEO, Lankenau Institute for Medical Research Editor-in-Chief, Cancer Research  (他說兩大要件: (1) Pathological relevalence (2) Translational relevance. 若是一堆western

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EBV Infection-II

EBV Infection-II 由 ingrid 在 三, 04/23/2014 – 11:41 發表 EBV and KSHV EBV infection NP460hTERT OKB2 #1由 ingrid 在 一, 04/28/2014 – 17:16 發表。 雖然細胞培養在不對的培養液中,但病毒綠光感染率仍有13%(w/TGF-b1)。 #2由 ingrid 在 一, 05/05/2014 – 14:56 發表。 WB結果顯示測不到Rta及Zta蛋白質的表現 #3由 EVKVLIN 在 二, 04/29/2014 – 09:14 發表。 恭喜, 但不懂.. 這次不是改正成養在正確的medium中了嗎? 妳是說infection前細胞都是養在DF-K的意思嗎? Infection 時 細胞density仍然小於70%嗎? #4由 mmiiee 在 二, 04/29/2014

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2014/10/20 CMU Mini-symposium on Transcription, Epigenetics and Stem Cell

Dear All, On behalf of the organization committee, I like to invite you to join 2014 CMU Mini-symposium on Transcription, Epigenetics and Stem Cell to be held at China Medical University at Taichung from 12:30 to 5:30 pm on Oct 20 of 2014. We are very pleased to have three world leading scientists Yi Zhang, Hongkui Deng

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