Epigenetic Talks Bing Ren

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Dear All,
I like to invite you to join two exciting Epigenetic Talks by the world leading scientists Yi Zhang and Bing Ren on Oct 23 and Nov 4, respectively, at Academia Sinica.
Bing Ren
UCSD
Regulation of the 3D Genome
11 am, Nov 4, 2014
B1 Auditorium, IMB, Academia Sinica
Dr. Bing Ren, Member of Ludwig Institute for Cancer Research San Diego Branch and Professor at Department of Cellular and Molecular Medicine UCSD School of Medicine, is one of the top scientists worldwide in deep sequencing in both biology study and innovative technology development and one of the World’s Most Influential Scientific Minds in 2014 selected by Thomas Reuters.  We strongly believe that his visit will advance our view towards this explosive field and may very likely stimulate significant progress of our local genome-wide study and international collaboration. 
Representative publications: 
Jin F, Li Y, Dixon JR, Selvaraj S, Ye Z, Lee AY, Yen CA, Schmitt AD, Espinoza CA, Ren B.
Nature. 2013 Nov 14;503(7475):290-4. doi: 10.1038/nature12644. Epub 2013 Oct 20.
Rivera CM, Ren B.
Cell. 2013 Sep 26;155(1):39-55. doi: 10.1016/j.cell.2013.09.011. Review.
Hon GC, Rajagopal N, Shen Y, McCleary DF, Yue F, Dang MD, Ren B.
Nat Genet. 2013 Oct;45(10):1198-206. doi: 10.1038/ng.2746. Epub 2013 Sep 1.
Xie W, Ren B.
Science. 2013 Jul 19;341(6143):245-7. doi: 10.1126/science.1236254. Review. No abstract available.
Xie W, Schultz MD, Lister R, Hou Z, Rajagopal N, Ray P, Whitaker JW, Tian S, Hawkins RD, Leung D, Yang H, Wang T, Lee AY, Swanson SA, Zhang J, Zhu Y, Kim A, Nery JR, Urich MA, Kuan S, Yen CA, Klugman S, Yu P, Suknuntha K, Propson NE, Chen H, Edsall LE, Wagner U, Li Y, Ye Z, Kulkarni A, Xuan Z, Chung WY, Chi NC, Antosiewicz-Bourget JE, Slukvin I, Stewart R, Zhang MQ, Wang W, Thomson JA, Ecker JR, Ren B.
Cell. 2013 May 23;153(5):1134-48. doi: 10.1016/j.cell.2013.04.022. Epub 2013 May 9.
Smallwood A, Ren B.
Curr Opin Cell Biol. 2013 Jun;25(3):387-94. doi: 10.1016/j.ceb.2013.02.005. Epub 2013 Mar 4. Review.
Shen Y, Yue F, McCleary DF, Ye Z, Edsall L, Kuan S, Wagner U, Dixon J, Lee L, Lobanenkov VV, Ren B.
Nature. 2012 Aug 2;488(7409):116-20. doi: 10.1038/nature11243.
Yu M, Hon GC, Szulwach KE, Song CX, Zhang L, Kim A, Li X, Dai Q, Shen Y, Park B, Min JH, Jin P, Ren B, He C.
Cell. 2012 Jun 8;149(6):1368-80. doi: 10.1016/j.cell.2012.04.027. Epub 2012 May 17.
Dixon JR, Selvaraj S, Yue F, Kim A, Li Y, Shen Y, Hu M, Liu JS, Ren B.
Nature. 2012 Apr 11;485(7398):376-80. doi: 10.1038/nature11082.
Xie W, Barr CL, Kim A, Yue F, Lee AY, Eubanks J, Dempster EL, Ren B.
Cell. 2012 Feb 17;148(4):816-31. doi: 10.1016/j.cell.2011.12.035.
Espinoza CA, Ren B.
Nat Genet. 2011 Jun 28;43(7):615-6. doi: 10.1038/ng.869. No abstract available.
Hawkins RD, Hon GC, Ren B.
Nat Rev Genet. 2010 Jul;11(7):476-86. doi: 10.1038/nrg2795. Review.
Ren B.
Nature. 2010 May 13;465(7295):173-4. doi: 10.1038/465173a. No abstract available.
Hawkins RD, Hon GC, Lee LK, Ngo Q, Lister R, Pelizzola M, Edsall LE, Kuan S, Luu Y, Klugman S, Antosiewicz-Bourget J, Ye Z, Espinoza C, Agarwahl S, Shen L, Ruotti V, Wang W, Stewart R, Thomson JA, Ecker JR, Ren B.
Cell Stem Cell. 2010 May 7;6(5):479-91. doi: 10.1016/j.stem.2010.03.018.
Heintzman ND, Hon GC, Hawkins RD, Kheradpour P, Stark A, Harp LF, Ye Z, Lee LK, Stuart RK, Ching CW, Ching KA, Antosiewicz-Bourget JE, Liu H, Zhang X, Green RD, Lobanenkov VV, Stewart R, Thomson JA, Crawford GE, Kellis M, Ren B.
Nature. 2009 May 7;459(7243):108-12. doi: 10.1038/nature07829. Epub 2009 Mar 18.
Maynard ND, Chen J, Stuart RK, Fan JB, Ren B.
Nat Methods. 2008 Apr;5(4):307-9. doi: 10.1038/nmeth.1194. Epub 2008 Mar 16.
Kim TH, Abdullaev ZK, Smith AD, Ching KA, Loukinov DI, Green RD, Zhang MQ, Lobanenkov VV, Ren B.
Cell. 2007 Mar 23;128(6):1231-45.
Heintzman ND, Stuart RK, Hon G, Fu Y, Ching CW, Hawkins RD, Barrera LO, Van Calcar S, Qu C, Ching KA, Wang W, Weng Z, Green RD, Crawford GE, Ren B.
Nat Genet. 2007 Mar;39(3):311-8. Epub 2007 Feb 4.
Kim TH, Barrera LO, Zheng M, Qu C, Singer MA, Richmond TA, Wu Y, Green RD, Ren B.
Nature. 2005 Aug 11;436(7052):876-80. Epub 2005 Jun 29.
Yi Zhang
Howard Hughes Medical Institute/Harvard Medical School
Mechanism and Function of Tet-mediated DNA Demethylation
Plenary Speaker
15th IUBMB-24th FAOBMB-TSBMB
2:45 to 3:25 pm, Oct 23, 2014
中研院人文館國際會議廳
Dr. Yi Zhang is one of the Top 10 High Impact authors in the world in the fields of Molecular Biology and Genetics from 2002 to 2006 and one of the World’s Most Influential Scientific Minds in 2014 selected by Thomas Reuters.  His breakthrough discoveries of key enzymes in epigenetics include (1) histone deacetylase NuRD complex, (2) almost all histone methyltransferases, (3) histone ubiqutin E3 ligase, (4) the JmjC domain-containing histone demethylases, and (5) enzymes involved in DNA demethylation (the top burning issue in epigenetics) and the brand new DNA bases.  His lab has published more than 150 outstanding papers and more than 1/2 are in Cell/Nature/Science, their sister journals and Gene Dev. 
Representative Publications:
Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes. Shen L, Inoue A, He J, Liu Y, Lu F, Zhang Y*. Cell Stem Cell. 2014 Oct 2;15(4):459-70.
Reversing DNA methylation: mechanisms, genomics, and biological functions. Wu H, Zhang Y*. Cell. 2014 Jan 16;156(1-2):45-68.
Role of Tet1 in erasure of genomic imprinting. Yamaguchi S, Shen L, Liu Y, Sendler D, Zhang Y*. Nature. 2013 Dec 19;504(7480):460-4. Epub 2013 Dec 1.
Tet1 controls meiosis by regulating meiotic gene expression. Yamaguchi S, Hong K, Liu R, Shen L, Inoue A, Diep D, Zhang K*, Zhang Y*. Nature. 2012 Dec 20;492(7429):443-7. Epub 2012 Nov 14.
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y*. Science. 2011 Sep 2;333(6047):1300-3. Epub 2011 Jul 21.
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell massspecification. Ito S, D’Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y*. Nature. 2010 Aug 26;466(7310):1129-33.
A role for the elongator complex in zygotic paternal genome demethylation. Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y*. Nature. 2010 Jan 28;463(7280):554-8. Epub 2010 Jan 6.
Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Tateishi K, Okada Y, Kallin EM, Zhang Y*. Nature. 2009 Apr 9;458(7239):757-61. Epub 2009 Feb 4.
Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Okada Y, Scott G, Ray MK, Mishina Y, Zhang Y*. Nature. 2007 Nov 1;450(7166):119-23. Epub 2007 Oct 17.
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Klose RJ, Yamane K, Bae Y, Zhang D, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y*. Nature. 2006 Jul 20;442(7100):312-6. Epub 2006 May 28.
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y*. Cell. 2006 May 5;125(3):483-95. Epub 2006 Apr 6.
Histone demethylation by a family of JmjC domain-containing proteins. Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y*. Nature. 2006 Feb 16;439(7078):811-6. Epub 2005 Dec 18.
hDOT1L links histone methylation to leukemogenesis. Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y*. Cell. 2005 Apr 22;121(2):167-78. Erratum in: Cell. 2005 Jun 3;121(5):809.
Role of histone H2A ubiquitination in Polycomb silencing. Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y*. Nature. 2004 Oct 14;431(7010):873-8. Epub 2004 Sep 22.
Role of histone H3 lysine 27 methylation in X inactivation. Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, Wang H, de la Cruz CC, Otte AP, Panning B*, Zhang Y*. Science. 2003 Apr 4;300(5616):131-5. Epub 2003 Mar 20.
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y*. Science. 2002 Nov 1;298(5595):1039-43. Epub 2002 Sep 26.
Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Wang H, Huang ZQ, Xia L, Feng Q, Erdjument-Bromage H, Strahl BD, Briggs SD, Allis CD, Wong J, Tempst P, Zhang Y*. Science. 2001 Aug 3;293(5531):853-7. Epub 2001 May 31.
Look forward to seeing you!!
Best, Li-Jung
Li-Jung Juan, PhD
Associate Research Fellow
Genomics Research Center
Academia Sinica
128 Academia Rd, Sec 2, Nankang, Taipei 115, Taiwan, ROC
Tel: 02-27871234 (O), 02-27898775 (Lab), 0928613826 (Mobil)
Fax: 02-27898811
Email: ljjuan@gate.sinica.edu.tw

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