AK457-leftover (7 OSCC cell lines)

DDR1-related GoodNotes 5 紀錄

2016.02.5546 Kumara / Reinhardt

• Fibronectin targeted drug delivery in cancer
• Alternative splicing of the precursor mRNA produced from the single copy fibronectin gene, occurrs at three sites coding for the EDA, EDB, and IIICS domains
• Fibronectin isoforms comprising the EDA or EDB domains are known as oncofectal forms due to their developmental importances and their re-expression in tumors, contrasting with restriction presence ?? in normal adult tissues.
• Attributed to this feature, EDA and EDB domains have been extensively used for the trageted delivery of cytokines, cytotoxic agents chemotherapy drugs and radio isotopes to FN1-expressing tumors to ? therapeutic effects on primary causes and metastatic lesions.
• In addition to drug delivery, the EDA and EDB domains of FN1 have also been utilized to develop imaging stratagies for tumor tissues
• Furthermore, EDA and EDB based vaccines seem to be promising for the treatment and prevention of certain cancer types.

2017.07.4978 Hirata / Erik Saha @ UK

• TME and differential response to therapy
• Cancer evolution (development of tumors and response to therapies)
• tumor evoluation is shaped by the environment
• TME – a complex mixture of non-transformed cell types and ECM
• Composition of tumor microenvironment
  • endothelial cells
  • fibroblasts
  • macrophages
  • neutrophils
  • dendritic cells
  • cytotoxic T cells
• Cancer-stroma interplay under cytotoxic reagents
• stromal modulation of responses to radiotherapy
• microenvironmental protection from targeted therapies

2019.06.5543 Rick …Aghi

• FN1 in malignancy: cancer-specific ??
• protumoral effects and therapeutic implications
• Therapy targeting fibronectin is based on two effects
  • EDA/EDB expression is primarily limited to sites of malignancy in adults
  • cellular fibronectin appears to play a role in cancer pathogenesis.

2020.02.5546 pdf___ Gong … Dai (Google search by combining target FN1 and clinical trail)

• Stage IV breast cancer –> metastatic lung cancer
• dual-acting therapeutic strategy: doxorubicin (D) + vinorelbine (V)
• CREKA (Cys-Arg-Glu-Lys-Ala) D V mi;
• pentapeptide –> target FN1 complex fibron-FN1

2020/02/18–––Xena on 40TN

2020/03/07 GoodNotes 5 筆記抄錄–我有大發現

1. OC3 hg38 vs TW2.6 hg38, “FGF” 共23筆
   • FGF1: OC3 >> TW2.6
   • FGF2: OC3 > TW
   • FGFR1-OP: OC3 >>TW
   • FGFR3 OC3 << TW
2. oralcancer-2017

2020/04/23 黃智興委員針對續聘一事做關懷

2020/05/03 For OC3-NOG paper Discussion 最後兩段

CAFs as a whole 先舉4篇例子: PDAC 2014 (25259922 Sherman), CRC 2015, TBNC 2018, HNC 2020; 再加上 Sahai review (31980749); Miyai (32060987) 提醒versatility 及小心使用

1. 2014.09.4178-PDAC-25259922. Shermen. VitD receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapies. Shermen and RM Evans
2. 2015.02.5049 (25706627) Isella et al., -stromal contribution to CRC (we describe here that a CAF-specific stromal signature recapitulates the clinical attributes of the SSH subgroup, that is, higher intrinsic aggressive and better response to chemotherapy.) We also provide new evidence that CAF, endothelial and leukocytes jointly predict the response of rectal cancer to radiotherapy. High expression of the CAF signatures was associated iwth poor prognosis in untreated CRC; high expression of the stromal signatures predicted resistance to radiotherapy in rectal cancer.
3. 2018.09.5540. Breast cancer, Cazet, Swarbrick et al., 30042390. Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer; Hedgehog signaling to CAFs as a novel meiator of CSC plasticity and an exciting new therapeutic target in triple negative breast cancer
   • SMOi
4. HNC pdf 5547-32028632-Yegodayev

2020/08/07 GoodNotes 5 筆記抄錄

1. design .gmt for
   1. YHL (2019/08–mouse Tuveson 3/3 pdf 5267)
   2. TYL (2019/09– human UCSF Jun S. Song Group pdf 5589)
   3. LRH-AK027 (2019/10)–mouse pdf 5638 Peter Sims & Doma Farber)
2. pdf 3703, CAF-N and CAF-D
3. pdf 5267, iCAF myCAF, apCAF
4. pdf 5589, 8 stages of keratinocytes
   • supplementary File 1
   • stage 4 is a mitotic stage
   • stage 8 is a channel cluster
5. pdf 5638, 7 stages of T-cell activation
   • Source data Fig S4a
   • Note that “mouse version” is required
   • 加一組 KEGG: T-cell activation
6. 17p13: TP53 and 17p13 deletion

2021/10左右某個星期二參加YSL及連醫師meeting

THP1 –> M1 –> 分泌 IL8

dexemethone