07/18 小丸報告

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1.為了補強DDR1 paper的圖表，重新做了shAXL, shDDR1, shEGFR, shFGFR3的實驗，發現它們對OSCC細胞的生長抑制作用(WST-1 assay)有程度上的差異，其中DDR1在48h對細胞的抑制平均而言可達三成左右。
2.取OEC-M1為cell model，證實Glivec可以降低DDR1 auto-phosphorylation之程度。
3.Collagen type IV處理的HOK及TW2.6細胞中，可見及DDR1表現量增加，其餘細胞的相關實驗則由小夏幫忙檢測中。

2 thoughts on “07/18 小丸報告”

  1. 小丸子

    1. Four potential PTKs silenced caused differential effect on growth inhibition in OSCC cells.
    2. Tyrosine phosphorylation of DDR1 could be decreased by Glivec in OEC-M1 cells. 3. Collagen type IV induced DDR1 expression in HOK and TW2.6 cells.
    4. Glivec treatment had less effect on HOK cell growth.

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