原文Nature.
Next, we performed immunohistochemistry (IHC) on approximately 115 human tissues ranging from benign nevi to metastatic melanoma (tissue set 1). mH2A2 antibody was used for IHC, as it produced clear nuclear staining, and tissues were independently scored by two blinded dermatopathologists with excellent interobserver consistency. IHC demonstrated that although mH2A2 is abundantin melanocytes of benign nevi and RGP lesions, its expression is dramatically lost in more than 80% of VGP and metastatic melanomas ….