11/17 Lab Meeting- 小夏

報告這篇PAPER
1. LMP1 increases the release of EGFR into exosomes and that purified exosomes containing LMP1 and EGFR are taken up by epithelial, endothelial, and fibroblast cells, leading to the activation of ERK and PI3K/Akt pathways.
2. The ability to detect LMP1 in the exosome pellet harvested from serum of mice carrying the C15 tumor supports a physiological role of LMP1-containing exosomes in NPC.
3. EBV miRNAs have been detected in NPC exosomes.
4. The effects of EBV and LMP1 on exosomes are likely to be important factors in EBV infection through which a small number of cells expressing LMP1 could both modulate the tumor microenvironment and also potentially impact the infected host.