Bill Sugden (McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, USA) “How EBV Prevails During Productive Infection” Hybrid of P3HR1 and D98. (Endogenous P3HR1 cells) EBV’s lyticv phase commandeers the cell much as do a-herpesviruses Determining when vEBV DNA amplifies following induction off the productive cycle (treated cells with tamoxifen —> BZLF 1 expression) Tamoxifen was […]
Paul Farrell (Imperial College London, United Kingdom) –”EBV Genome Sequence Variation: Geography, Function and Disease” J Virol. 2017 Jul 12;91(15). Natural Variation of Epstein-Barr Virus Genes, Proteins, and Primary MicroRNA. (PubMed Link) 138 new EBV genomes, 125 of these combined with 116 others = 241 Analysis of 241 aligned EBV genomes in multiple sequence alignment Type1/Type2
Irving Weissman (Stanford University School of Medicine, USA) “Normal and Neoplastic Stem Cells” Marrow or MPB (mobilized peripheral blood) Mixture of cells: HSCs, T cells, cancer cells Deplete mature blood cells by labeling with magnetic antibodies Pure HSCs for transplantation 250,000 fold depletion an ever cells or T cells Unwanted cells : cancer cells, T
Patrick Moore (University of Pittsburgh, USA) “Why Do Viruses Cause Cancer?” PubMed Link (pdf 2803) Viruses do not “mean” to cause cancer • Cancer endangers virus as well as host • Viruses non-transmissible in tumors (eg latency, pseudo-latency) • Virus populations Limited resource hypothesis: enhancing lyric virus replication tumor virus targets at G1 phase Infection is
Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model. (PubMed Link)
2018/06/28 Journal Club Read More »
Day 1院長致詞: 十一月份還會有一個retreat Emerging Trends and Opportunities for Microbiota Research高承源副研究員 (免疫醫學中心)– Microbiota is not just about bacteria, viruses, fungi are also included.– Analytic tools of microbiota (e.g.assembling the human gut Microbiota in metabolic diseases. – 16S/26S RNA sequencing)– Metaproteomics workflow– Models for human microbiota research– Organ-on-a-chip RootChip (different levels of oxygen at different layers of
Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast ActivationProtein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice. (PubMed Link)
2018/06/07 Journal Club Read More »
An OX40/OX40L interaction directs successful immunity to hepatitis B virus. (PubMed Link)
2018/05/14 Journal Club Read More »
Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions. (PubMed Link)
2018/05/10 Journal Club Read More »
Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. (PubMed Link) The 神’s webpagehttps://wistar.org/our-scientists/dmitry-gabrilovich
2018/04/26 Journal Club Read More »