1. 下次開會: 6月
2. CA OrCA PIs + 王副院長、莊JL、陳YR、黃HG (RA:雪君)、江主秘。
3. BioSignature Program: Leader/Chang Gung 核醫科主任閻紫宸, looking for cause-effect marker. The third meeting will be held on March-8; focus on miRNA/epigenetics/DNAs; funding source, Academia Sinica.
4. 王副院長Lab學生報告 (Wei-Chieh Huang)—長庚閻醫師 has 53 OrCA T/N pairs; miR-491-5p is involved in cell migration and invasiveness, targeting GIT1 and RAB1; OC-3 and C9 were used。
5. Dr. 莊JL
Cellular prion is increased by alcohol consumption involved in tumorigenesis of OSCC
PrpSC/PRNP is significantly up-regulated in OSCC
以電腦判讀TMA result
Second primary tumor (what is the definition of second primary? second primary vs. recurrent)
Alcohol induced TGF-b1 elevaltion is modulated by PrpC
6. 雪君:
Small heat shock protein
HSP27, 60, 70, 90, 110 MW 10–30 are called as small HSP
HSPB1=HSP27
She uses HOK, Cai-27, OC3, OEC-M1, Ca9-22 as cell models
HSP27/HSPB1 enhances OSCC apoptosis via repression in response to oxidative stress
H2O2 (50 uM), ANE (10 ug/ml), ANE (30 ug/ml)
PKCdelta and PTP1B function as downstream of HSP27/HSPB1 in response to oxidative stress.