0624 (Sunday night)
- Prof George SW Tsao: 186 participants (66 China, 44 Hong Kong, 20 Industry)
- Keynote Session: Viruses, Cancer and Stem Cell [06/24 PM]
- led by Alan Rickinson (University of Birmingham, United Kingdom)
- In memory of Thomas Turse 1946-2018 (start to work on EBV since 1979s’ ; an oncologist; stromatolites-tumor in NPC; organizer of EBV meeting at Annecy France in 1994)
Patric Moore (Why Do Viruses Cause Cancer?)
Irving Weissman (Normal and Neoplastic Stem Cells)
0625 Monday (Day 2)
- EBV Infection and NPC Pathogenesis [06/25 AM]
- led by Alan Chiang (The University of Hong Kong, Hong Kong SAR China)
Paul Farrell (EBV Genome Sequence Variation: Geography, Function and Disease)
Bill Sugden (How EBV Prevails During Productive Infection)
Rebecca Skalsky (regulation of Host Signaling Pathways by EBV miRNAs)
Bo Zhao (NPC Epigenetic Landscapes and Super-Enhancers)
Selected from Poster Abstracts:
Lin Feng (Nasopharyngeal carcinoma susceptibility gene TNFRSF19 inhibits TGFß signaling and promotes tumorigenesis)
Miao Xu (Genome sequencing analysis identifies Epstein- Barr virus subtypes associated with the risk of nasopharyngeal carcinoma)
- Regulation of Lytic and Latent EBV Infection [06/25 PM]
- led by Mei-Ru Chen (National Taiwan University, Taiwan)
Shannon Kenney (Differentiation-Dependent Lytic EBV Reactivation in Epithelial Cells)
Lori Frappier (New Functions for EBV Proteins in Manipulating Cellular Processes Important for Cancer)
Mu Sheng Zeng 曾木聖 (The Key Cellular Factors in EBV Infection of Epithelial Cells)
0626 Tuesday (Day 3)
- Risk Factors and Novel Markers for NPC [06/26 AM]
- led by Jin-Xin Bei 貝錦新 (Sun Yat-Sen University Cancer Center, China)
Wei-Hua Jia (Genetic Predisposition of Nasopharyngeal Carcinoma: Evidence from GWAS and Sequencing Studies)
Jin-Ching Lin 林進清 (Application of Plasma EBV DNA Assay in Daily Practice of NPC Management)
Dennis Lo 盧煜明 (Plasma EBV DNA for – Screening Nasopharyngeal Carcinoma)
Maria Lung (New Insights in NPC Detection Utilizing Circulating Tumor Cell Enumeration and NGS Analysis)
Scott Bratman (Circulating Tumor DNA: Detection and Applications in Curable Cancers)
- Molecular Profiling of NPC [06/26 PM]
- led by Andrew Futreal (University of Texas MD Anderson Cancer Center, USA)
Kwok Wai Lo 羅國煒 (Acquired Genomic Changes in Nasopharyngeal Carcinoma)
Wei Dai (Genetic Susceptibility in Nasopharyngeal Carcinoma)
Daniel De Carvalho (Translational Aspects of DNA Methylation in Cancer)
Selected from Poster Abstracts:
Ming-Han Tsai 蔡明翰 (The M81 Epstein-Barr Virus Associated RNA2 Enhances CXCL8 Production and Spontaneous Virus Lytic Replication in Primary B Lymphocytes)
0627 Wed (Day 4)
- Tumor Microenvironment of NPC [06/27 AM]
- led by Eric Stanbridge (University of California, Irvine, USA)
Pierre Busson (Galectin-9 and Other Factors of Immune Escape in NPC Tumor Microenvironment: How to Bring Them Under Control?)
Maria Massucci (A Role of Bacterial Co-Infection in the Pathogenesis of NPC?)
Selected from Poster Abstracts:
Alan Chiang
(Novel Mechanism of Induction of Lytic Cycle of Epstein-Barr Virus (EBV) in EBV-Positive Epithelial Malignancies Through Intracellular Iron Chelation)
Scott Bratman
Selected from Poster Abstracts:
Alan Chiang
(Novel Mechanism of Induction of Lytic Cycle of Epstein-Barr Virus (EBV) in EBV-Positive Epithelial Malignancies Through Intracellular Iron Chelation)
Scott Bratman
(ISNLx Regulates Cellular Metabolic Reprogramming and Is a Potential Therapeutic Target for Nasopharyngeal Carcinoma)
Jun Zhang
(Epstein-Barr Virus-Encoded LMP1 Reprograms Glucose Metabolism to Drive Cell Motility Through mTORC2/PDHE1α-Mediated Histone Acetylation in Nasopharyngeal Cells)
Xuefeng Liu (ROCK inhbibitor J Pathol Author, Georgetown U)
(Patient-Derived Cell Models and Next Generation Living Biobanks (NGLB) for Precision Medicine)
Dewi Kartikawati Paramita
(NPC Strip G: Rapid Test Strip Detecting IgG Against EBV Antigens in NPC)
Jun Zhang
(Epstein-Barr Virus-Encoded LMP1 Reprograms Glucose Metabolism to Drive Cell Motility Through mTORC2/PDHE1α-Mediated Histone Acetylation in Nasopharyngeal Cells)
Xuefeng Liu (ROCK inhbibitor J Pathol Author, Georgetown U)
(Patient-Derived Cell Models and Next Generation Living Biobanks (NGLB) for Precision Medicine)
Dewi Kartikawati Paramita
(NPC Strip G: Rapid Test Strip Detecting IgG Against EBV Antigens in NPC)
- Challenges and Novel Approaches in NPC Treatment [06/27 PM]
- led by Brian O’Sullivan (University of Toronto, Canada)
Danny Rischin (Role of Chemotherapy in NPC: Not Novel, but Still Challenging)
Jun Ma 馬駿 (Comprehensive Treatment Strategy in Locoregionally Advanced Nasopharyngeal Carcinoma)
Anne Lee (Challenges and Novel Approaches in Radiotherapy for Nasopharyngeal Carcinoma)
Troy Messick (Development of an EBNA1 Inhibitor for the Treatment of NPC: Toward First-in- Human Studies)
0628 Thu (Day 5)
- Immunotherapy of NPC [06/28 AM]
- led by Dora Kwong 鄺麗雲 (University of Hong Kong, Hong Kong SAR China)
Lillian Siu (Immune and Other Biomarkers of Resistance to Anti-PD1 Therapy in NPC)
Rajiv Khanna (Adoptive T Cell Therapy for NPC: Immune Correlates to Immune Contexture)
Graham Taylor (The NPC Immunotherapy Landscape)
Han Chong Toh (Cellular Immunotherapy for Nasopharyngeal Cancer: Learning from the Past for a Better Tomorrow)
Brigette Ma (Immune Checkpoint Inhibitor in the Treatment of Nasopharyngeal Carcinoma: A Clinical Overview)
Rajiv Khanna (Adoptive T Cell Therapy for NPC: Immune Correlates to Immune Contexture)
Graham Taylor (The NPC Immunotherapy Landscape)
Han Chong Toh (Cellular Immunotherapy for Nasopharyngeal Cancer: Learning from the Past for a Better Tomorrow)
Brigette Ma (Immune Checkpoint Inhibitor in the Treatment of Nasopharyngeal Carcinoma: A Clinical Overview)
- Keynote Session: Future Perspectives in NPC Research and Treatment
- led by Quynh-Thu Le (Stanford University, USA)
Tak Mak (Beyond Targeting Oncogenes: Future Anti-Cancer Strategies)
Lawrence Young (The Future of NPC Research: Opportunities and Challenges)
Poster I (6/25 4-6 PM)
|
#
|
Name
|
Affiliation
|
Co-Author(s)
|
Poster Title
|
Category
|
|
01
|
Abdul Aziz, Norazlin
|
Institute for Medical Research
|
Marini Marzuki, Nurul Ashikin Mohd Shahrehan, Susan Ling Ling Hoe, Lu Ping Tan, Geok Wee Tan, Noor Kaslina Mohd Kornain, Kin Choo Pua, Cheng Eng Koay, Chai Chiun Hian Sebastian Dominic Ling Chuo Shern
|
Histological and molecular characterization of nasopharyngeal carcinoma patient-derived xenografts
|
Translational
|
|
02
|
Aimjongjun, Sathid
|
Mahidol University
|
Muhammad Asaduzzaman, Shang Yao, Paula Saavedra- García, Tavan Janvilisri, Eric Wing-Fai Lam
|
Lapatinib resistance in nasopharyngeal carcinoma is mediated through Sirt2- modulated FOXO3 deacetylation
|
Basic
|
|
03
|
Baloche, Valentin
|
Gustave Roussy
|
Using the CT26 syngenic tumor model for basic and pre-clinical investigations on galectin-9, an immuno- suppressive protein abundantly expressed by malignant NPC cells
|
Translational
|
|
|
04
|
Bratman, Scott
|
Princess Margaret Cancer Centre
|
Jeffrey Bruce, Ting Ting Wang, Jinfeng Zou, Caberry WeiYang Yu, Marco Di Grappa, Zhen Zhao, Yanqiao Zheng, Shao Hui Huang, Trevor Pugh, John Waldron, Lillian Siu, Fei-Fei Liu
|
EBV-Seq for ultrasensitive detection of nasopharynx cancer from plasma cell- free DNA
|
Clinical
|
|
05
|
Cao, Sumei
|
Sun Yat-Sen University Cancer Center
|
Ting Hu, Qing Liu, Shang-Hang Xie, Chu- yang Lin, Geng-hang Chen
|
Smoking is associated with a persistent EBV reactivation and long-term increased nasopharyngeal carcinoma (NPC) risk: an analysis of a prospective NPC screening cohort in southern China
|
Clinical
|
|
06
|
Chai, Wai Yeeng
|
Cancer Research Malaysia
|
Sok Ching Cheong, Hui Mei Lee, Pei San Yee, Stacey Price, Emanuel Gonclaves, Fiona Behan, Ultan McDemott, Matthew Garnett
|
Genome-wide CRISPR- Cas9 knockout screen in EBV-positive NPC cell line reveals vulnerabilities to members of the NF/kB pathways
|
Basic
|
|
07
|
Chan, Tsz Fung
|
The University of Hong Kong
|
Hui KF, Shen JJ, Lam KP, Yang W and Chiang AK
|
Identification of several distinct clusters of type 1 and type 2 EBV harbored in Hong Kong Chinese carriers showing significant variations from EBV isolated from other geographic
|
Clinical
|
|
08
|
Chen, Chi- Ju
|
National Yang-Ming University
|
Dai-Rong He, Chong- Yu Chao, Hsin Guo
|
MSK1-mediated CREB activation is important for EBV reactivation
|
Basic
|
|
09
|
Chen, Lin
|
Sun Yat-Sen University Cancer Center
|
Jing Yuan, Jingshu Xiao, Lin Chen, Yi-Fan Lian, Xue-Kang Qi, Jin- Xin Bei, Yi-Xin Zeng, and Lin Feng.
|
SHROOM2 suppresses nasopharyngeal carcinoma metastasis by inhibiting epithelialmesenchymal transition in a RhoA-ROCK pathway-independent manner
|
Basic
|
|
10
|
Chen, Yupei
|
Sun Yat-Sen University Cancer Center
|
Ling-Long Tang, Qi Yang, Sharon-Shuxian Poh, Edwin P Hui, Anthony TC Chan, Whee-Sze Ong, Terence Tan, FRCR, Joseph Wee, Wen-Fei Li, Lei Chen, Brigette BY Ma, Macy Tong, Sze-Huey Tan, Shie
|
Induction chemotherapy plus concurrent chemoradiotherapy in endemic nasopharyngeal carcinoma: individual patient data pooled analysis of four randomized trials
|
Clinical
|
|
11
|
Cheong, Sok Ching
|
Cancer Research Malaysia
|
The use of dual-antigen peptide to stimulate immune responses in head and neck cancer patients
|
Translational
|
|
|
12
|
Chiang, Alan
|
The University of Hong Kong
|
Kwai Fung Hui, Pei Tung Yiu, Chung King Choi, Richard Yi Tsun Kao, Dan Yang
|
A novel mechanism of induction of lytic cycle of Epstein-Barr virus (EBV) in EBV-positive epithelial malignancies through intracellular iron chelation
|
Basic
|
|
13
|
Chung, Grace
|
The Chinese University of Hong Kong
|
Yvonne Yan-Yan Or, Zoey Wing-Yee Liu, Ka- Fai To, Kwok-Wai Lo
|
Epigenetic alterations of TGFß signaling pathway in EBV-associated nasopharyngeal carcinoma
|
Basic
|
|
14
|
Chiu, Ya- Fang
|
Chang Gung University
|
Arthur U. Sugden, Kathryn Fox, Mitchell Hayes, and Bill Sugden
|
Kaposi’s sarcoma– associated herpesvirus stably clusters its genomes across generations to maintain itself extrachromosomally
|
Basic
|
|
15
|
Dai, Danling
|
Sun Yat-Sen University Cancer Center
|
Ping Han, Mu-Sheng Zeng
|
Novel chimeric transcript RRM2-c2orf48 promotes metastasis in nasopharyngeal carcinoma
|
Basic
|
|
16
|
Daker, Maelinda
|
Institute for Medical Research
|
Paul Matthew Neilsen, Munirah Ahmad, Alan Soo-Beng Khoo
|
Silvestrol: a protein synthesis inhibitor as a potential targeted therapy against NPC
|
Basic
|
|
17
|
Deng, Mingdan
|
The University of Hong Kong
|
AKL Cheung, W Dai, HY Ng, ML Lung
|
Functional and molecular analysis of the somatic mutations in two NF-?B pathway inhibitors, NFKBIA and CYLD, in nasopharyngeal carcinoma
|
Basic
|
|
18
|
Du, Yun
|
Cancer Research Institute of Zhongshan City, Zhongshan City People’s Hospital
|
Wentong Zhang, Feng Lei, Zhuming Li, Xiaodong Liu, Yanan Ni, Li Deng, Mingfang Ji
|
Long-term outcomes of intensity-modulated radiotherapy for nasopharyngeal carcinoma: a retrospective analysis of survival and treatment toxicities in a prefecture-level hospital in China
|
Clinical
|
|
19
|
Fachiroh, Jajah
|
Universitas Gadjah Mada
|
T. Baning Rahayujati, Suhada Suhda, Dwi Hartati, Camelia Herdini
|
Genetic and environmental risk factors of nasopharyngeal carcinoma in Indonesia
|
Clinical
|
|
20
|
Feng, Lin
|
Sun Yat-Sen University Cancer Center
|
Chengcheng Deng, Yuxin Lin, Xue-Kang Qi, Gui-Ping He, Yuchen Zhang, Hao-Jiong Zhang, Miao Xu, Qi- Sheng Feng, Jin-Xin Bei, Yi-Xin Zeng and Lin Feng
|
Nasopharyngeal carcinoma susceptibility gene TNFRSF19 inhibits TGFß signaling and promotes tumorigenesis
|
Basic
|
|
21
|
Feng, Ruimei
|
Sun Yat-Sen University Cancer Center
|
Ellen T. Chang, Zhiwei Liu, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Jian- Yong Shao, Wei-Hua Jia, Yuming Zheng, Jian Liao, Yu
|
Reproductive history and risk of nasopharyngeal carcinoma based on a population-based case– control study in southern China
|
Clinical
|
|
22
|
Hau, Tom Pok Man
|
The Chinese University of Hong Kong
|
Kwok Wai Lo
|
Characterization of fusion protein UBR5-ZNF423 in nasopharyngeal epithelial cells
|
Basic
|
|
23
|
He, Yongqiao
|
State Key Laboratory of Oncology in South China
|
Wen-Qiong Xue, Jiang- Bo Zhang, Jianbing Mu, Wei-Hua Jia
|
The relationship between environmental factors and the profile of Epstein-Barr virus antibodies in the lytic and latent infection periods in healthy populations from endemic and non-endemic nasopharyn
|
Clinical
|
|
24
|
Hoe, Susan
|
Institute for Medical Research
|
Lu Ping Tan, Norazlin Abdul Aziz, Kitson Liew, Mohd. Firdaus Che Mat, Suziana Zaila Che Fauzi, Sin-Yeang Teow, Fazlyn Reeny Abdul Razak, Christine Ricky, Nurul Ashikin Mohamed Shahrehan, Tai Lin Chu
|
Patient-derived xenografts as preclinical models for cancer stem cells and therapeutic studies in NPC
|
Translational
|
|
25
|
Hu, Ting
|
Sun Yat-Sen University Cancer Center
|
Shang-Hang Xie, Chu- yang Lin, Geng-hang Chen, Su-Mei Cao
|
Smoking is associated with a persistent EBV reactivation and long-term increased nasopharyngeal carcinoma (NPC) risk: an analysis of a prospective NPC screening cohort in southern China
|
Clinical
|
|
26
|
Huang, Chor Mei
|
The University of Hong Kong
|
Anna CM Tsang
|
Promotion of In Vivo Growth of Epstein-Barr Virus (EBV)-associated Nasopharyngeal Carcinoma by miR-BARTs
|
Basic
|
|
27
|
Hui, Kwai Fung
|
The University of Hong Kong
|
AKS Chiang
|
Induction of Epstein-Barr virus lytic cycle in EBV- associated epithelial malignancies by dual actions of histone deacetylase inhibitors and a novel organic compound
|
Basic
|
|
28
|
Janvilisri, Tavan
|
Mahidol University
|
Sathid Aimjongjun, Onrapak Reamtong
|
Glycoproteomic comparison between nasopharyngeal carcinoma cells with different metastatic potential
|
Basic
|
|
29
|
Ji, Mingfang
|
Cancer Research Institute on Zhongshan City
|
Tingdong Li, Fugui Li
|
Establishment and validation of a two-step screening scheme for improved performance of serological screening of nasopharyngeal carcinoma
|
Clinical
|
|
30
|
Jia, Lin
|
The University of Hong Kong
|
Yim Ling Yip, Weitao Lin, Kit San Yuen, Dong-Yan Jin, George SW Tsao
|
Regulation of lytic Epstein- Barr virus replication in a newly established nasopharyngeal cancer cell line
|
Basic
|
|
Poster Session 2: Tuesday June 26th, 2:00-4:00 pm
|
|||||
|
#
|
Name
|
Affiliation
|
Co-Author(s)
|
Title
|
Category
|
|
01
|
Keppen, Chenole
|
Healthcare Laboratory and Research Centre, Naga Hospital Authority Kohima
|
Vinotsole Khamo, Wetetsho Kapfo, Subhash Medhi
|
Association of HSPA1B with nasopharyngeal carcinoma in Naga population of Northeast India
|
Clinical
|
|
02
|
Khamo, Vinotsole
|
Naga Hospital Authority Kohima
|
Visenuo Aiko, Chenole Keppen
|
EBV determination of Nasopharyngeal Carcinoma in Naga population of North-East India
|
Clinical
|
|
03
|
Khoo, Alan
|
Institute for Medical Research
|
Norazlin Abdul Aziz, Ng Wooi Loon, Johnny SH Kwan, Cheng-Eng Koay, Kwok-Wai Lo, Munirah Ahmad, Alan Soo-Beng Khoo
|
Spontaneous Lytic Reactivation of Epstein- Barr virus in lymphoid xenografts from nasopharyngeal carcinoma patients
|
Translational
|
|
04
|
Ko, Josephine
|
The University of Hong Kong
|
Maria Li Lung
|
Telomere length associates with risk of NPC and survival of late stage IV patients
|
Translational
|
|
05
|
Kontny, Udo
|
RWTH University Hospital Aachen
|
Anna Makowska, Lora Wahab, Till Braunschweig, Nikiforos-Ioannis Kapetanakis, Christian Vokuhl, Bernd Denecke, Lian Shen, Pierre Busson
|
Interferon beta induces apoptosis in nasopharyngeal carcinoma cells via the TRAIL- signaling pathway
|
Basic
|
|
06
|
Lee, Hui Min
|
University of Malaya
|
APE Sia, H Sathasivam, GSW Tsao, PG Murray, IC Paterson, LF Yap
|
Downregulation of monoamine oxidase A (MAOA) by EBV infection promotes NPC cell migration
|
Basic
|
|
07
|
Leong, Man Long
|
The University of Hong Kong
|
Arthur Kwok Leung Cheung, Wei Dai, Sai Wah Tsao, Maria Li Lung
|
EBV-associated histone modifications in the regulation of DNA damage repair members resulting in cisplatin resistance in nasopharyngeal carcinoma
|
Basic
|
|
08
|
Li, Lili
|
The Chinese University of Hong Kong
|
Xu J, Wang Z, Qiu G, Ying J, Du Z, Chan AT, Chan FKL, Ambinder RF, Tao Q
|
Epigenomic identification and functional characterization of novel tumor suppressor genes (TSGs): a p53-regulated 3p22.2 TSG represses oncogenic STAT3 signaling via protein docking
|
Basic
|
|
09
|
Li, Shibing
|
Sun Yat-Sen University Cancer Center
|
Li Yuan, Yanyan Liu, Jianhua Sui, Qian Zhong, Musheng Zeng
|
ISNLx regulates cellular metabolic reprogramming and is a potential therapeutic target for nasopharyngeal carcinoma
|
Translational
|
|
10
|
Li, Yongshu
|
The University of Hong Kong
|
Chanping You, Chi Man Tsang
|
Development of molecular probes for surface markers on LMP1-positive nasopharyngeal cancer cell using aptamer selected by Cell-SELEX
|
Basic
|
|
11
|
Lim, Chwee Ming
|
National University of Singapore
|
Anthony Kian-Fong Liou, Gwyneth Soon, Louise Tan, Wei-Kin Chong, Shi Wang, Chwee-Ming Lim
|
IL18 from NPC induced PD-1 expression on NK cells in TILS leading to poor prognosis
|
Translational
|
|
12
|
Liu, Na
|
Sun Yat-Sen University Cancer Center
|
Na Liu, Yingqin Li, Qingmei He, Xin Wen, Jun Ma
|
EZH2-DNMT1-mediated epigenetic silencing of miR-142-3p promotes metastasis through targeting ZEB2 in nasopharyngeal carcinoma
|
Basic
|
|
13
|
Liu, Tengfei
|
The University of Hong Kong
|
Pei Shin Pang, Weitao Lin, Chi-Man Tsang, Elaine Yip, Zhou Yuan, Xin-Yuan Guan, Sai- Wah Tsao, Wen Deng
|
Defining early events of EBV infection in immortalized nasopharyngeal epithelial cells using cell-free EBV infection
|
Basic
|
|
14
|
Liu, Xuefeng
|
Georgetown University
|
Patient-Derived Cell Models and Next Generation Living Biobanks (NGLB) for Precision Medicine
|
Translational
|
|
|
15
|
Lung, Hong Lok
|
Hong Kong Baptist University
|
On Ying Man
|
How the serum amyloid A1 (SAA1) genetic variants differentially modulate the focal adhesion in nasopharyngeal carcinoma (NPC) cells?
|
Basic
|
|
16
|
Mai, Zhi- Ming
|
The University of Hong Kong
|
Sai-Yin Ho, Roger Kai- Cheong Ngan, Dora Lai-Wan Kwong, Wai- Tong Ng Alice Wan- Ying Ng, Kam-Tong Yuen, Kai-Ming Ip, Yap- Hang Chan, Anne Wing-Mui Lee, Maria Li Lung, Tai-Hing Lam
|
Are exposure to sunlight, dietary vitamin D intake, serum and genetically derived 25-hydroxyvitamin D risk factors of nasopharyngeal carcinoma (NPC)?
|
Clinical
|
|
17
|
Mejia, Michael
|
Benavides Cancer Institute
|
Ryan Anthony F Agas, Paolo G Sogono
|
Outcomes with Reirradiation for Recurrent Nasopharyngeal Carcinomas: Experience from a Tertiary Academic Center in a Developing Country
|
Clinical
|
|
18
|
Ngernsomb at, Chawalit
|
Mahidol University
|
Warut Tulalamba, Noppadol Larbcharoensub, Tavan Janvilisri
|
Transcriptomic profiling reveals potential biomarkers for recurrence of nasopharyngeal carcinoma
|
Translational
|
|
19
|
Ning, Lvwen
|
The University of Hong Kong
|
Josephine Mun Yee Ko, Maria Li Lung
|
Targeted gene sequencing studies of CDKN2B-AS1 in nasopharyngeal carcinoma genetic susceptibility
|
Translational
|
|
20
|
Paramita, Dewi Kartikawati
|
Universitas Gadjah Mada
|
Fachiroh J, Sumartiningsih, Suhda S, Kiely S, Herdini C, Ardiningtyas B
|
NPC Strip G: Rapid Test Strip Detecting IgG against EBV Antigens in NPC
|
Clinical
|
|
21
|
Paterson, Ian
|
University of Malaya
|
Tan ML, Parkinson EK, Yap LF
|
Relationship between autophagy, activation and senescence in normal and cancer-associated fibroblasts from the head and neck
|
Basic
|
|
22
|
Prattapong, Pongphol
|
Mahidol University
|
Thana Narkthong, Alisa Damnernsawad, Supeecha Kumkate, Tavan Janvilisri
|
Anticancer activities of baicalein against nasopharyngeal carcinoma
|
Basic
|
|
23
|
Qi, Xuekang
|
Sun Yat-Sen University Cancer Center
|
Hui-Qiong Han, Hao- Jiong Zhang, Miao Xu, Lili Li, Lin Chen, Tong Xiang, Qi-Sheng Feng, Tiebang Kang, Chao- Nan Qian, Mu-Yan Cai, Qian Tao, Yi-Xin Zeng, Lin Feng
|
OVOL2 links stemness and metastasis via fine-tuning epithelial-mesenchymal transition in nasopharyngeal carcinoma
|
Basic
|
|
24
|
Ruuskanen, Miia
|
Turku University Hospital
|
Irjala H, Minn H, Vahlberg T, Randen- Brady R, Hagstrom J, Syrjanen S, Leivo I
|
Epstein-Barr virus and human papillomaviruses are favourable prognostic factors in Finnish nasopharyngeal carcinoma – a nationwide study
|
Clinical
|
|
25
|
Shair, Kathy Ho Yen
|
University of Pittsburgh
|
Elizabeth A. Caves, Sarah A. Cook, Phillip Ziegler, Nara Lee, Donna Stolz, Simon Watkins and Kathy H.Y. Shair
|
Application of the air liquid interface (ALI) culture method to study EBV pathogenesis in polarized airway epithelia
|
Basic
|
|
26
|
Tang, Wing Chung
|
The University of Hong Kong
|
Anna CM Tsang, J Zhang, CP You, Gareth E Jones, George SW Tsao
|
Induction of invadosomes formation in EBV-infected nasopharyngeal carcinoma cells by M2 macrophages and LMP1 expression
|
Basic
|
|
27
|
Tian, Jinxiu
|
Sun Yat-Sen University Cancer Center
|
Hao-Jiong Zhang, Jinxiu Tian, Xue-Kang Qi, Tong Xiang, Gui- Ping He, Hua Zhang, Xibao Yu, Xiao Zhang, Bingchun Zhao, Qi- Sheng Feng, Ming- Yuan Chen, Musheng Zeng, Yi-Xin Zeng and Lin Feng
|
Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation
|
Basic
|
|
28
|
Tsai, Ming- Han
|
National Yang-Ming University
|
Zhe Li, Ming-Han Tsai, Remy Poirey, Anatoliy Shumilov, Henri- Jacques Delecluse
|
The M81 Epstein-Barr virus associated RNA 2 enhances CXCL8 production and spontaneous virus lytic replication in primary B lymphocytes
|
Basic
|
|
29
|
Tsang, Anna Chi- Man
|
The University of Hong Kong
|
Wilson WC Tang, Gareth E Jones, George SW Tsao
|
The impact of invadosomes in promoting the invasiveness of nasopharyngeal carcinoma (NPC) under the interplay of stromal macrophages and EBV infection
|
Basic
|
|
30
|
Tay, Joshua
|
Stanford University School of Medicine
|
Chunfang Zhu, Shirley Zhu, Sujay Vennam, Joseph Foley, Quynh- Thu Le, John Sunwoo, Robert West
|
Gene expression in nasopharyngeal carcinoma by laser capture microdissected transcriptome sequencing
|
Translational
|
|
Poster Session 3: Wednesday June 27th, 4:00-6:00 pm
|
|||||
|
#
|
Name
|
Affiliation
|
Co-Author(s)
|
Poster Title
|
Category
|
|
01
|
Wang, Fang
|
Sun Yat-Sen University Cancer Center
|
Fang Wang, Tong-Min Wang, Jiang-Bo Zhang, Wei-Hua Jia
|
Germline mutations in DNA polymerase POLN are associated with familial nasopharyngeal carcinoma
|
Translational
|
|
02
|
Wang, Tongmin
|
Sun Yat-Sen University Cancer Center
|
Tong-Min Wang; Guo- Ping Shen; Ming-Yuan Chen; Jiang-Bo Zhang; Ying Sun;Wei-Hua Jia
|
A prospective multi-stage study identified CEP128 as a susceptibility gene for radiation-induced brain injury
|
Clinical
|
|
03
|
Wang, Ya- Qin
|
Sun Yat-Sen University Cancer Center
|
Yu-Pei Chen, Yu Zhang, Wei Jiang, Na Liu, Jing-Ping Yun, Ying Sun, Qing-Mei He, Xin- Ran Tang, Xin Wen, Xiao-Jing Yang
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Prognostic significance of tumor-infiltrating lymphocytes in nondisseminated nasopharyngeal carcinoma: A large-scale cohort study
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Clinical
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04
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Wong, Wee Lin
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University of Malaya
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Lee HM, Tsao GSW, Haigh T, Murray PG, Taylor G, Khoo AS, Yap LF, Paterson IC
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Influence of cancer- associated fibroblasts on immune evasion in NPC
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Basic
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05
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Xiang, Tong
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Sun Yat-Sen University Cancer Center
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Wen-Long Ma, Hao- Jiong Zhang, Ke-Ming Chen, Gui-Ping He, Qi- Sheng Feng, Yi-Xin Zeng, Lin Feng.
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A role of EBV in vascular mimicry formation via AKT/HIF-1a pathway in EBV-associated epithelial malignancies
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Translational
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06
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Xu, Miao
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Sun Yat-Sen University Cancer Center
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You-Yuan Yao, Shanshan Zhang, Su- Mei Cao, Zhe Zhang, Weimin Ye, Hans-Olov Adami, Xihong Lin, Jianjun Liu, Yi-Xin Zeng
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Genome sequencing analysis identifies Epstein- Barr virus subtypes associated with the risk of nasopharyngeal carcinoma
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Clinical
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07
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Xue, Zhichao
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The University of Hong Kong
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Preclinical study of PD- 0332991 on EBV-positive NPC cell lines and xenografts
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Translational
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08
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Yap, Lee Fah
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University of Malaya
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Lee HM, Haigh T, Wong WL, Tsao GSW, Murray PG, Taylor G, Paterson IC, Yap LF
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The contribution of Epstein-Barr virus to the impaired T-cell responses in nasopharyngeal carcinoma
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Basic
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09
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Yip, Yim Ling
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The University of Hong Kong
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Weitao Lin, Wen Deng, Lin Jia, Kwok Wai Lo, Pierre Busson, Benjamin Vérillaud, Xuefeng Liu, Chi Man Tsang, Maria Li Lung, Sai Wah Tsao
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Establishment of a nasopharyngeal carcinoma cell line capable to undergo EBV lytic reactivation
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Basic
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10
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Yiu, Stephanie
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The University of Hong Kong
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Pei Tung Yiu, Kwai Fung Hui, Chung King Choi, Richard Yi Tsun Kao, Dan Yang and Alan Kwok Shing Chiang
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Autophagy is essential in promoting EBV lytic reactivation by a novel compound, C7, in EBV- positive nasopharyngeal carcinoma
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Basic
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11
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You, Chanping
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The University of Hong Kong
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Wilson WC Tang, Gareth E Jones, George SW Tsao, Anna CM Tsang
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Topographic guidance of the formation of invadopodia in EBV- infected nasopharyngeal epithelial cells induced by TGF-beta1
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Basic
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12
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Warren, Marshelle
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Viracta Therapeutics, Inc.
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Robert McRae, Preston Daniels
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Epigenetic regulation of Epstein Barr virus: a promising therapeutic target for the treatment of nasopharyngeal carcinoma
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Translational
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13
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Zhang, Jiang-bo
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Sun Yat-Sen University Cancer Center
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Wang Tong-Min, Huang Shao-Yi, Dong Si-Qi, He Yong-Qiao and Jia Wei-Hua
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Natural variations in BRLF1 promoter from nasopharyngeal carcinoma endemic areas contributes to the elevated reactivation level of Epstein-Barr virus
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Clinical
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14
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Zhang, Jun
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The University of Hong Kong
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Lin Jia, Tengfei Liu, Yim Ling Yip, Wing Chung Tang, Weitao Lin, Wen Deng, Kwok Wai Lo, Chanping You, Maria Li Lung, Gareth E Jones, Lai-Man Cheung, Chi Man Tsang, Sai Wah Tsao
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Epstein-Barr virus-encoded LMP1 reprograms glucose metabolism to drive cell motility through mTORC2/PDHE1a- mediated histone acetylation in nasopharyngeal cells
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Basic
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15
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Zhang, Xiao
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Sun Yat-Sen University Cancer Center
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Bingchun Zhao, Mingmei Ding, Haojiong Zhang, Xibao Yu, Tong Xiang, Ling Gao, Miao Xu, Lin Feng, Qisheng Feng, Musheng Zeng, Qinjian Zhao, Yixin Zeng.
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A novel vaccine candidate based on chimeric VLP displaying multiple conserved epitopes induce neutralizing antibodies against EBV infection
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Translational
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16
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Zhao, Bing- chun
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Sun Yat-Sen University Cancer Center
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Xiao Zhang, Claude Krummenacher, Shuo Song, Ling Gao, Haojiong Zhang, Miao Xu, Lin Feng, Qisheng Feng, Musheng Zeng, Yuting Xu, Yixin Zeng
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Immunization with Fc- based recombinant Epstein-Barr virus gp350 elicits potent neutralizing humoral immune response in a BALB/c mice model
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Translational
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17
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Zhong, Qian
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Sun Yat-Sen University Cancer Center
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Zhi-Hua Liu, Zhi-Rui Lin, , Li Yuan, Yan-min Liu, Ai-Jun Zhou, Xin- Yuan Guan, Ling Guo, Hai-Qiang Mai, Ming- Yuan Chen, Fei Han, Yun-Fei Xia, Mu-Sheng Zeng
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The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma
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Translational
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18
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Zhu, Junyu
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The Chinese University of Hong Kong
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Chi-Hang Wong, Brigette B.Y. Ma, Connie W.C. Hui, Kwok-Wai Lo, Edwin P. Hui, Anthony T.C. Chan
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Preclinical evaluation of the synergistic effects of LEE011 and BYL719 in nasopharyngeal carcinoma
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Translational
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19
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Zhu, Qian- Ying
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Sun Yat-Sen University Cancer Center
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Jiang-Yi He, Mu-Sheng Zeng
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Overexpression of Nogo receptor 3 (NgR3) correlates with poor prognosis and contributes to the migration of epithelial cells of nasopharyngeal carcinoma patients
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Translational
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20
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Cho, William
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Queen Elizabeth Hospital
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Victor Wan-San Ma
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A multiplex fluorescent application for the co- localization of Epstein-Barr viral RNA and xenobiotic detoxification enzyme in nasopharyngeal carcinoma and lymphoepithelioma-like carcinoma of lung
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Basic
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21
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Lui, Vivian
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The Chinese University of Hong Kong
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Hoi-Lam Ngan, Lan Wang, Kwok-Wai Lo
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Re-analysis of whole- exome sequencing data of EBV(+) NPC and HPV(+) HNSCC reveals genomic commonalities in major patient subsets
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Translational
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22
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Lin, Su- Fang
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National Health Research Institutes
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Abstract link | conference program link | |
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23
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Cheung, Lydia WT
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The University of Hong Kong
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24
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Chua, Melvin LK
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National Cancer Centre Singapore
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25
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Liu, Xu
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Sun Yat-Sen University Cancer Center
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26
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Wu, Dinglan
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Shenzhen Hospital, The Southern Medical University
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27
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Zhang, Yuan
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Sun Yat-Sen University Cancer Center
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0621 楔子 + 行前預習
好快，又二年了!
- 回來後記得將NP460hTert reads拉出來，和GA514後面五株細胞統一做alignment
- 考慮做下一批RNA-seq時, 是否要treat NP460hTert, NP550hTert with TGFB1 24h
- miRNAs 要進來嗎?
- Immune evasions
- viral parts BNLF2a, vIL10, miRNAs?
- host parts (don’t eat me (CD47) eat me (CALR)
- Kathy HY Shair @ U Pittsburg (過去與Nancy Raab-Traub做過), 建議我們要注意Ca++濃度宜在0.8-0.9 mM, 並且 Venn Diagram要一個一個做
0625 Monday (Day 2)
0625 Monday (Day 2)
EBV Infection and NPC Pathogenesis
led by Alan Chiang (The University of Hong Kong, Hong Kong SAR China)
- Latency II, LMP1+ LMP1- LMP1+ LMP1 highly heterogeneous
- MHC I gene mutation. NFKB
- How EBV contributes to NPC : some critical questions
- are pathogenic EBV variants linked to NPC ?
- – Prof Paul Farrell on variation of EBV genomic sequence
- – Dr. Xu Miao on EBV subtypes in NPC (Poster 7)
- Lytic activity of EBV in epithelium and NPC
- – Prof Bill Sugden on how EBV prevails during productive infection
- – Shannon Kenny
- Viral and host factors
- – Rebecca Skalskyon regulation of host signaling pathways by EBV miRNAs
- – Dr. Feng Lin on TFNR
- – Epigenetic
- – Cancer heterogeneity
Regulation of Lytic and Latent EBV Infection
led by Mei-Ru Chen (National Taiwan University, Taiwan)
(list contributions and achievements of each speakers, very nice!)