Tak Mak

由 sufang 在 日, 11/02/2014 – 11:09 發表 Pre-published Cancer Metabolism Notes Youtube https://www.youtube.com/watch?v=nFelWNxpdWk Genomic alterations in cancersmutations (300,000; > 20,000 genes)epithelial : 50-100; leukemia: 20amplifications (3000)deletions (thousands)translocations (fusions: 7000)epigenetic changes (extensive)Drivers : hundred, 90% loss of functionsInter-and intra-tumor heterogeneity (Charles Sweton)< 1/2 mutated or amplified genes expressed Two more oncometabolic papers from Harvard Groups: Nature (2011). Functional […]