sxl70

Nature Feb 2011 全文在此. “Single molecule is the future of sequencing, but it still has hurdles.”

讀到 Vol 9, Issue 19 而已… 02-2011

視窗: \prt-r2.nhri.org.tw (920832@nhri.org.tw yahoo)

剛剛再跟ingridko確認 當初 億康幫我們製作的KR Ab, 送出兩段peptide 分別是a.a.514-531與a.a.627-657 而我後來測試好用的660 是來自於a.a.627-657 有可能 認S634dm的能力較差 之後我會注意這點的

http://www.nature.com/nrc/journal/v11/n2/full/nrc3012.html It is generally assumed that tumours evolve through a progressive acquisition of mutations in the genome that allow cells to evade apoptosis, proliferate, invade and metastasize. However, in some instances one single event can lead to multiple coexisting mutations — the loss of telomeres results in end-to-end chromosome fusions that lead to chromosomal rearrangements.

原文Nature.Next, we performed immunohistochemistry (IHC) on approximately 115 human tissues ranging from benign nevi to metastatic melanoma (tissue set 1). mH2A2 antibody was used for IHC, as it produced clear nuclear staining, and tissues were independently scored by two blinded dermatopathologists with excellent interobserver consistency. IHC demonstrated that although mH2A2 is abundantin melanocytes of benign

(1) 夏興國：(a) 40 T/N. 三個miRNA clusters →14q32, 21q and X。其中 14q32 and 21q are down-regulated, whilst X region is up-regulated. (b) Xq26.24 (Wnt receptors) and 14q32.2 (Wnt ligand e.g., Wnt 2, Wnt 7A and 7B) seem to indicate Wnt pathway is involved in OSCC. (2) 張所長: (a) Metastasis MMP高CTSS高，但用藥卻failed. Serine protease may be more interesting!

淮山、芡實、茯苓、蓮子。

1. 地圖. 有日據時代名稱 (在”地圖檢索”Tab中).

Dr. 王陸海: STAT3 ↑, leads to CCND1 ↑, cMYC ↑ and TWIST ↑; TWIST → AKT2 activation→invasion ↑ and survival ↑ in BrCA cells.