Anne Lee (The University of Hong Kong, Hong Kong SAR China & The University of Hong Kong at Shunzen) “Challenges and Novel Approaches in Radiotherapy for Nasopharyngeal Carcinoma” HKNPC1301 study on IMRT (2001-2010) to further improve tomorrow control for poor risk group IMRT: parotid sparing (randomized trials on IMRT (late toxicity following IRT) Radiotherapy – […]
Danny Rischin (Peter MacCallum Cancer Centre, Australia)“Role of Chemotherapy in NPC: Not Novel, but Still Challenging” Discussion Leader (Brian OSuillivan): Danny Rischin is a leader of HNSCC! 哈，找了下PubMed還真的做許多HNSC相關研究 e.g. J Oral Pathol Med. 2018 Jan;47(1):18-24. The role of human papillomavirus in p16-positive oral cancers.Belobrov S1, Cornall AM2,3,4, Young RJ5, Koo K6, Angel C7, Wiesenfeld D1,6,8, Rischin
Maria Massucci (Karolinska Institutet, Sweden)“A Role of Bacterial Co-Infection in the Pathogenesis of NPC?” in immunosuppressive considerations. EBV positivity1. Immunotherapy blasting clymohoma (60&) CNS localization (100%)3. Post-transplant lymphoma (100%)4. Lymphoma of the elderly (100%)5. Leiomyosarcoma (smooth muscles)[evidence suggesting the involvement of bacterial infections in NPC pathogenesis]• NPC is often associated with chronic bacteria infections
Pierre Busson (Gustave Roussy, France)“Galectin-9 and Other Factors of Immune Escape in NPC Tumor Microenvironment: How to Bring Them Under Control?” Overview of TME [Co-evolution of tumor and stroma]M. Here’s at al, J Pathol 2013 (squamous-columnar junction cells From tumor micro environment to tumor macro-environment A gradient from tumor interstitial to the bloodstream Distant site:
Daniel De Carvalho (University Health Network / University of Toronto, Canada)“Translational Aspects of DNA Methylation in Cancer” [DNA Methylation patterns are tissue specific and conserved across individuals] Deconvoluting the tumor microenvironment from DNA methylation data CYBERSORT to profile TME TILS DNA methylation patterns are reprogrammed in cancer patients but retain tissue-specificitcirculating cell-free DNA (cfDNA) [Cancer
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Wei Dai (The University of Hong Kong, Hong Kong SAR China)“Genetic Susceptibility in Nasopharyngeal Carcinoma” multiple genetic effects in the NPC susceptibility genes allele frequency can WES-seq if NPC identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma [Gene Level replicaiton study in NPC] NPC cases (n=1131, FamilyHIstory FH+=258) MST1R deleterious covariant s of
Scott Bratman (Princess Margaret Cancer Centre, Canada)“Circulating Tumor DNA: Detection and Applications in Curable Cancers” Can liquid biopsy replace it’s sue biopsy?EGFR-mutant NSCLC: ctDNA analysis is standard for guiding EGFR How about applied to cancers that are curable CtDNA < 1% total cell DNA Nat Rev Wan… Rosenfield et al. Nat Rev Cancer 2017 Rasta
Maria Lung (University of Hong Kong, Hong Kong SAR China)“New Insights in NPC Detection Utilizing Circulating Tumor Cell Enumeration and NGS Analysis” NPC AoE Research Tissue Bank (http://www.cnpcr.hku.hk/tb1.htm) CTCs and CtDNA (Dr. Lin, JC and Dennsi Lo) provide different and complementary information Cancer Research 2013. (Pastel and Alex Panabieres) Real time liquid biopsy in
Jin-Ching Lin (National Yang-Ming University, Taiwan)“Application of Plasma EBV DNA Assay in Daily Practice of NPC Management” [Tumor Biomarkers in NPC]– serum anti-EBV antibody– Serum/plasma EBV DNA– Others (many molecular markers reported bu no any one can be used clinically) [Comparison of sensivity and specificity In J Radiat Oncol Biol Phys 2007; 67:130-7 [Ideal Tumor
Wei-Hua Jia (Sun Yat-sen University Cancer Center, China)“Genetic Predisposition of Nasopharyngeal Carcinoma: Evidence from GWAS and Sequencing Studies” # Spatial and temporal patterns of MNOC mortality in China (1973-2005) showed significant decreased Compared with those living in North China, residents living in Southern China had a much higher risk in the Familial clustering has been