徐偉展

Dear all I would like to discuss my study on B cell-specific PTEN deletion mice at 2/14 (四). The title is “Characterization of the inflammatory syndrome in B cell-specific PTEN deleted mice”. Best regard. Wei Chan

Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, MetabolicReprogramming, and Heme Biosynthesis. (PubMed Link)

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination. (PubMed Link)

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. (PubMed Link)

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. (PubMed Link)

Serine Is an Essential Metabolite for Effector T Cell Expansion. (PubMed Link)

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming PubMed Link Wei-Chan的slides <按我預覽或下載>

Succinate is an inflammatory signal that induces IL-1β through HIF-1α. <PubMed連結> Wei-Chanの slide <按我預覽或下載> ——————————————————–2014/06/20  咦, 有PubPeer alert呦…Christos Chinopoulos | Jun 20 2014 05:48 EST Could it be that LPS-induced succinate over-production is due to itaconate formation? LPS induces Irg1, a gene coding for cis-aconitate decarboxylase, specifically expressed in cells of macrophage lineage Proc Natl