July 5, 2016

GRC NPC – Ma, J and Bei, JX

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2018 GRC NPC Jun Ma (Sun Yat-Sen Medical University, China)“Comprehensive Treatment Strategy in Locoregionally Advanced Nasopharyngeal Carcinoma” Evolving National Comprehensive Cancer Network’s (NCCN) guidelines (2018) of the nasopharynx Lancet Oncol. 2016 Nov;17(11):1509-1520.  Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial. Sun Y1, […]

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GRC NPC – Longnecker, R

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Richard Longnecker (Northwestern University, USA)“EBV Entry into Host” Lindsey Hutt-Fletcher retires last year. Give all the reagents to Longnecker.Cell-cell fusiongp42 and MHC II structure.Soluble gb42 stimulates fusion with B cells but inhibits fusion with epithelials. From Ming-HanLongnecker: EBV entrygp350 gHgL gB BMRF2gB( gp110) is highly conserved in HerpesvirusgHgL against avb6)gHgL+gp42: against MHCII   3D structure(Mbio

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GRC NPC – Lo, Yuk-Ming Dennis

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2016 GRC NPC Dennis Lo (Chinese University of Hong Kong, Hong Kong SAR China)  “Plasma DNA Analysis for Detecting NPC: Biological Insights and Clinical Applications” 盧煜明 (Wiki https://goo.gl/HTNGFn) 香港中文大學網站 https://goo.gl/03EPTe    http://goo.gl/i7PNRf ) Size based molecular diagnosis (difference between maternal and fetal , because the fetal DNA has no linker, therefore is 10 bp shorter)

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GRC NPC – Fuchs, Elaine

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Elaine Fuchs (The Rockefeller University, USA HHMI Investigator) “Transition of Normal Epithelia to Cancer”Webpage http://www.rockefeller.edu/research/faculty/labheads/ElaineFuchs/#content a student of Howard Green, who just passed away several mo ago The foundation of embryonic stem cell culture to come in 1980s burn therapy quiescent stem cell and primed stem cells awaiting for activation Hair follicle stem cells BMP signaling

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GRC NPC – Clevers, H

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Hans Clevers (Hubrecht Institute, The Netherlands)“Wnt Signaling and Cancer” The champion of all stem cells : crypt base paneth cells Wnt is required to maintain crypt stem cells in colon cancer，Wnt is locked in On state。 Lqr5 is an unusual component that marks stem cells in the crypts。 15 stem cell to begin  (mixed with1

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GRC NPC – Lo, KW

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2018 GRC NPC [NPC tumorigenesis model] WES-seq of 111 NPC patient Nat Commun 18: 14121, 2017 LCM enrichment of tumor cells. -> higher somatic mutation than the Singapore study (because of LCM?) LMP1 activates both canonical and non-canonical NFKB pathways Homozygous deletion f BIRC2(cIAP) and BIRC3(cIAP2) in primary NPC Identification of a novel 12p13.3 amplicon

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