January 2013

GSVA – gene set variation analysis for microarray and RNA-Seq data

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GSVA – gene set variation analysis for microarray and RNA-Seq data Gene set enrichment (GSE) analysis is a popular framework for condensing information from gene expression profiles into a pathway or signature summary. The strengths of this approach over single gene analysis include noise and dimension reduction, as well as greater biological interpretability. As molecular profiling […]

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NRF2 and p53: Januses in cancer?

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OncoTarget 2013-Jan Link Abstract The transcription factor nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or NRF2, is a master regulator of the anti-oxidative stress response and positively controls the expression of a battery of anti-oxidative stress response proteins and enzymes implicated in detoxification and glutathione generation. Although its detoxifying activity is important in

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20130116Lab meeting-小丸

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1. 利用pooled shDDR1 clones探討DDR1對於OSCC cells的影響，結果發現抑制DDR1表達造成OSCC cells數目降低及細胞凋亡數目增加，而p-SHC、p-SHP2、p-MAPK、CDK1及bcl2為參與DDR1 pro-survival 路徑的重要分子。 2. 比較一系列DDR1 inhibitors (Imatinib、Dasatinib及Nilotinib )對於OSCC cells生長的影響，其中Dasatinib對於OSCC cells的生長抑制效果顯著，但其為廣效型抑制劑，相較之下對DDR1專一性較差，因此，之後實驗仍會著重於Imatinib及Nilotinib當作DDR1抑制劑，觀察對於OSCC cells生長的影響。 3. 利用HOK探討collagens是否會增加DDR1及collagens的protein及mRNA level表達，結果發現collagen typeIV扮演重要角色。

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DDR1, Integrin, Cell adhesion and more…

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Discoidin Domain Receptors Promote α1β1- and α2β1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation. (PLoS One. 2012;7(12):e52209)Xu H, Bihan D, Chang F, Huang PH, Farndale RW, Leitinger B. The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that bind to and are activated by collagens. Similar to collagen-binding β1 integrins, the

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