chromothripsis
http://www.nature.com/nrc/journal/v11/n2/full/nrc3012.html It is generally assumed that tumours evolve through a progressive acquisition of mutations in the genome that allow cells to evade apoptosis, proliferate, invade and metastasize. However, in some instances one single event can lead to multiple coexisting mutations — the loss of telomeres results in end-to-end chromosome fusions that lead to chromosomal rearrangements. […]